ChloropHore

ESYA’s proprietary A DNA-based ratiometric combination reporter of pH and Cl^–. It can measure two ion simultaneously from same location allowing high spatial resolution of organelles based on their chemical composition. It is relevant to diseases such as Niemann-Pick’s, as well as drug discovery and efficacy assays. This figure (Leung et al., Nat. Nanotechnol., 2018) illustrates ChloropHore-labelled lysosomes in human dermal fibroblast cells of a healthy individual and two Niemann-Pick’s patients.